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Inhibition of DPP-IV activity in wild-type mice by pharmacological agents results in improvement in glucose tolerance, whereas this effect has not been observed in DPP-IV knockout mice (Marguet et al
Udayakumar et al
These findings led to the production of BA analog or TGR5 agonist to induce GLP-1 production in vivo
This broader metabolic coordination is what distinguishes GLP-1 function from simple appetite suppression
