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A study of nearly 28,000 23andMe users who reported taking GLP-1 weight-loss medications, published in Nature, found that a mutation in GLP1R, the gene encoding the protein targeted by GLP-1 drugs, was modestly but significantly associated with greater weight loss

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The design involved multiple dosing schemes of oral semaglutide, including once-daily dosages of 2.5 mg, 5 mg, 10 mg, 20 mg or 40 mg

If you are on the maximum dose of semaglutide (2.4 mg for Wegovy) or tirzepatide (15 mg for Mounjaro), your peak drug levels are already near the top of the therapeutic range