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doi:10.1016/j.neuroscience.2011.02.023 27

The balance of the HPA axis is vital for maintaining physical and mental health, for both overactivity and underactivity of the HPA axis may contribute to diseases

In a rat model of MCAO-induced stroke, neurogenesis was increased by semaglutide treatment, as evidenced by significantly increased levels of neurogenesis-specific biomarkers including nestin (intermediate filament protein that is a known marker of neuronal progenitor cells), doublecortin (microtubule-associated protein considered to be a reliable marker of neurogenesis), stromal cell-derived factor-1 (SDF-1) (chemokine promoting endogenous regeneration in the ischemic brain), and its receptor CXCR4

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