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These medications are not licensed or recommended by NICE, the MHRA, or other UK regulatory bodies for cognitive impairment or dementia

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One possible cause for such controversy might be the substance-specific effects of saxagliptin, which could be attributed to off-target side effects of DPP4 enzyme, resulting in unexpected alterations of other bioactive substrates in the body
This has driven interest in alternative mechanisms and combination approaches that might deliver comparable efficacy with improved side effect profiles

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