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The largest body of evidence supports GLP-1 monotherapy as the first-line pharmacological approach for weight loss in eligible patients, with semaglutide and tirzepatide demonstrating sustained weight reductions of 15 to 22 percent of baseline body weight

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Other non-GLP-1 drugs include phentermine or phentermine-topiramate, which are stimulants or appetite suppressants

10.1016/j.pharmthera.2021.108044 62 LuZ.LiY.SynW