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Safety Management Considerations: Gastrointestinal side effects predominate, but are generally manageable via dose titration

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Characterization and role of glucagon-like peptide 1 receptor in the lacrimal gland: novel insights into diabetic Dry eye pathogenesis
The group with the highest dosage lost an average of 9.6 percent of their body weightaround 15 lbs for a 160-lb womancompared to 7 percent for the lower-dose group and 3.4 percent for the placebo group

Moreover, it is well known that IL-1 activates NLRP3 inflammasome via IL-1R-mediated NF-B activation [40]