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Calanna S, Christensen M, Holst JJ, et al

LTP, long-term enhancement

For the receptor mechanism that underlies this work, see how the GLP-1 receptor is structured and signals, and for how discovery connects to the wider therapeutic landscape, the full picture of GLP-1 and metabolic disease

Future experiments will determine whether loss of Klb expression in these neuronal populations impairs GLP-1RA weight loss across multiple high carbohydrate diets

GLP-1s are one of the most powerful tools in modern medicine offering benefits that may extend beyond weight loss to better metabolic health, cardiovascular function, and inflammation reduction