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Therefore, human ex vivo models consisting of skin explants cultured in vitro have been developed to study HS pathogenesis, although they exhibit high donor variability often driven by the anatomical site from which they derive or intrinsic factors [64]

24 The main cascades involved in the signal transduction of GLP-1R are summarized in Figure 2

Quick Answer: Most patients require long-term GLP-1 therapy because diabetes and obesity are chronic conditions, and discontinuation typically causes weight regain and worsening blood sugar control

Cardiovasc Diabetol (2020) 19(1):196

[22] reported a weight-independent effect of GIP receptor stimulation on insulin sensitivity