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Whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on extrahepatic tissues, or whether their action is direct, i.e., through activating GLP-1R on the hepatocytes, is still a controversial issue

Combining naltrexone and semaglutide may enhance weight loss through different biological pathways, but safety and efficacy depend on individual health factors and medical supervision

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GLP-1 and GIP are incretin hormones that help regulate blood sugar and appetite
