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The first clinical trial was a randomized, single-blind, exploratory trial that assessed the role of exenatide in 44 participants on dopaminergic treatment with wearing-off effects

Novo Nordisk, a pharmaceutical company based in Denmark, made the first of the recent blockbuster drugs, Ozempic, which emerged on the scene as a drug for people with diabetes

d-Allulose enhances postprandial fat oxidation in healthy humans

doi: 10.1172/JCI81975

This finding supports the role of glucose toxicity in DM-related dopaminergic dysfunction and cognitive impairment, suggesting that advanced glycation end products (AGEs) and their precursor methylglyoxal (MGO) are linked to cognitive impairment and changes in the dopaminergic system