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Regarding other GLP-1RAs, such as liraglutide and albiglutide, no dose adjustment is necessary in patients with renal impairment, as these drugs are not renally excreted

High Blood Press Cardiovasc Prev 24:107114 Tanaka A, Shimabukuro M, Okada Y, Sugimoto K, Kurozumi A, Torimoto K, Hirai H, Node K (2020) PROCEED trial investigators

Using both SGLT-2 and DPP-4 inhibitors as active comparators strengthened study validity, while register linkage minimized selection and recall bias by ensuring exposures were recorded independently of outcomes

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In turn, the body required less pancreatic insulin to flush out excess glucose because the rate at which glucose was entering the blood decreased