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Conclusions GLP-1RA therapy in patients with CS and associated metabolic disorders led to significant improvements in weight, BMI, and glycemic control without worsening cortisol dynamics or liver function

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However, the insulinotropic effect of incretins is diminished in type 2 diabetic patients, due in part to reduced expression of incretin receptors as a consequence of glucotoxicity

These updates reinforce the need for early detection and intervention, ensuring inclusive trials and access to therapies for all children, regardless of location or healthcare system