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[29] Combination drugs [edit] Some DPP-4 inhibitor drugs have received approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production

But the dual receptor activation means the gastrointestinal effects can be more intense, particularly during dose escalation

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Your prescribing physician should be part of that decision

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