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Materials and methods Literature search and search strategy Searches were conducted in a comprehensive manner for publications of relevant peer-reviewed papers and dissertations between 1990 and 2022 in the Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and Weipu website (VIP) databases for all clinical studies on GLP-1 interventions in AD without language restrictions, using the Medical Subject Headings (MeSH) terms such as glucagon-like peptide 1, Alzheimers disease and cognitive function

Metabolic adaptation, the body resetting its energy balance to a lower expenditure level during weight loss, means that the post-treatment metabolic rate is lower than before treatment began

Thats the window where interventions like GLP-1s may matter most

Chris Serres: What the medications do is they produce this natural hormone, in the gut

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