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Dose adjustment considerations: If gastrointestinal symptoms are severe or persistent despite these measures, contact your prescribing clinician to discuss: Slowing the dose escalation schedule Temporarily reducing the dose Taking a brief treatment pause (though this may affect weight loss progress) Switching to an alternative weight management medication if symptoms are intolerable The STEP trials demonstrated that slower dose titration can reduce the incidence and severity of gastrointestinal adverse effects

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In general, the trials included in the NMAs were high quality with adequate randomization and concealment of treatment allocation

The 490 Project has worked toward police accountability and transparency for years, throughout multiple administrations and all levels of government, yet LMPDs behavior remains unconstitutional and discriminatory, said Nancy Cavalcante, on behalf of The 490 Project