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These situations warrant medical advice

As described above, the STENO-2 trial demonstrated that intensive control of multiple risk factors, including not only glycaemic, BP and lipid management but also the use of antiplatelet therapy in primary prevention and treatment of albuminuria with blockers of the reninangiotensin system, reduces microvascular and macrovascular diabetes complications and potentially mortality risk [1, 2]

The wearing-off pattern is most pronounced during weeks one through four, before steady state is achieved

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Complete weight maintenance without pharmacological support proves difficult for most patients, reflecting the biological nature of obesity as a chronic disease requiring ongoing management