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GLP-1 receptor agonists: new treatment frontiers Given the early success of treating diabetes and obesity with glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their neurobiological effects, interest is mounting in identifying new clinical applications and repurposing of these drugs for the treatment of neuropsychiatric conditions

Diabetes, prediabetes and cancer mortality

Conclusion GLP-1RA medications should be considered in all eligible patients with type 2 diabetes whose HbA 1c is not at their individualised target, who have established atherosclerotic cardiovascular disease or who have a compelling need to promote weight loss or minimise hypoglycaemia

Furthermore, while MACE included mortality attributed specifically to cardiac causes, the broader definition of mortality within MAKE did not allow for precise attribution to renal causes due to the limitations of diagnostic coding

All standard semaglutide contraindications and warnings apply, including the boxed warning for thyroid C-cell tumors and pregnancy contraindication for Wegovy