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While the kinetic rate constants could not be accurately determined for GLP-1 QMP, GLP-1 QMP/LX (0.2 nM) showed an almost 600-fold higher binding affinity compared to GLP-1 WT (Fig

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Primary result at 15 mg: 22.5% mean body-weight reduction vs

Deletion of SIRT1 in the anorexigenic POMC neurons attenuates leptin sensitivity and reduces energy expenditure, whereas over-expression of SIRT1 in POMC neurons sensitizes leptin signals and elevates energy expenditure [151, 152]

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