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Discontinuation was defined as a gap of 60 days from the last GLP-1based treatment supply day, allowing for GLP-1 drug-type switching (eg, semaglutide to tirzepatide)

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doi:10.1001/jama.2023.24539 27

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These findings strongly suggest that SGLT2 inhibitors confer cardiovascular and renal protection through mechanisms independent of glycemic improvement

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Endocrinology 151, 30493060

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Many patients may find 8mg sufficient and not need to escalate to 12mg, especially if side effects are well-controlled at 8mg

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