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Significant variations in the count of glutamatergic neurons were noted between the Sal + Sal, Sal + Ex-4, Her + Sal, and Her + Ex-4 groups

Compared to individuals without steatosis, patients with NASH have an increased incidence of ASCVD (HR 1.37, 95% CI 1.101.72) [102] and fatal and nonfatal MACEs (OR: 1.64, 95% CI 1.262.13) [103]

Mol Endocrinol 2001

Thus, tirzepatide has demonstrated significant efficacy in lowering HbA1c levels and body weight in individuals with T2D, often surpassing the results seen with other antidiabetic agents