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How Oral Semaglutide Works in Your Body Semaglutide is a glucagon-like peptide-1 receptor agonist that signals your brain's hunger control centers to reduce appetite and increase fullness signals

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However, the exaggerated effect of GLP-1 on postprandial insulin secretion in surgical subjects is not significantly different in those with and without recurrent hypoglycaemia. This means that additional factors are probably involved in the hypoglycaemic response seen in some GB patients

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