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Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin

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Men in trials generally reported gastrointestinal side effects slightly less frequently than women

Obesity further impairs antitumor immunity by engendering an immunosuppressive environment that protects tumor cells from the cytotoxic effects of CD8+ tumor infiltrating lymphocytes (TILs) 69
