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Type 2 diabetes (T2D) is among the most prevalent chronic metabolic disorders worldwide - driven by insulin resistance, pancreatic dysfunction, obesity, and unhealthy lifestyles

Among these are the beta-cell hormone amylin and the intestinal L cell hormone glucagon-like peptide-1 (GLP-1)

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NIH researchers have identified the intracellular signalling pathways through which semaglutide and other GLP-1 receptor agonists induce weight loss, revealing why patient responses vary and treatment effects plateau over time.

Twenty-pound weight loss on semaglutide typically occurs over 46 months in clinical trials, though individual timelines vary widely based on baseline metabolic factors, adherence, and dose titration