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Description
Traditionally, treatment focused on weight loss and exercise, but GLP-1s now offer an additional therapeutic option

Psychoneuroendocrinology 65, 5466

"These results suggest that when GLP-1 receptor agonists are clinically indicated for cardiometabolic reasons, potential benefits for substance-related outcomes may be an added consideration in shared decision-making."

Potential Impact of GLP-1 Receptor Agonists on Erectile Function Existing data point to a positive role of exenatide in facilitating NOdependent smooth muscle relaxation within the corpus cavernosum, likely mediated by reduced NADPH oxidase activity

The clinical trial programme for semaglutide, including the STEP trials for weight management and SUSTAIN trials for diabetes, did not report POTS as an adverse event
