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Reutens AT, Jandeleit-Dahm K, Thomas M et al (2020) A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: protocol and statistical considerations

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During those titration weeks, you are on suboptimal doses that provide less appetite suppression and less weight loss benefit

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