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Description
Aspiration is not necessary for subcutaneous injections
The observation that the induced effect on insulin secretion is different when oral glucose was administered versus the same amount of glucose parenterally coined the term incretin effect, supporting the idea that some substances secreted in the intestines favored the release of insulin after ingestion [1]

Drop back to the previous dose and attempt escalation again after an additional 2-4 weeks

Having a small meal or snack with your drink can help buffer these effects

Biogerontology 9 , 110 (2008)
