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ligand binding makes the cleavage site accessible, leading to shedding of the Notch ectodomain as the first step of signal transduction [[3][3], [4][4]]
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The singer, 32, showcased her toned physique as she walked down the aisle with her beau Jordan 'Jutes' Lutes, 34, on Saturday during what appeared to be a rehearsal for their upcoming nuptials.
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