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Glucagon-like peptide-1 (GLP-1) protects against ischemia-reperfusion injury in patients with acute myocardial infarction (AMI)

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It is engineered to activate three distinct metabolic hormone receptors concurrently: Glucagon-like peptide-1 (GLP-1) receptor Glucose-dependent insulinotropic polypeptide (GIP) receptor Glucagon (GCG) receptor This tri-agonist architecture differentiates GLP-3R from earlier peptide constructs that selectively target only one or two receptor pathways

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