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In a letter, the FDA said it needs more data to fully understand several possible risks tied to the drug, including heart and liver problems.

In late 2025, a seemingly narrow advertising dispute told a much bigger story about the GLP-1 market

Roche reported positive Phase II topline data showing that its once-weekly dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist CT-388 achieved substantial, sustained, and dose-dependent weight loss through 48 weeks

Further research is warranted to elucidate underlying mechanisms and optimize patient selection.

Food and Drug Administration Adverse Events Reporting System (FAERS) database