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There also was no significant difference between tirzepatide and one-anastomosis gastric bypass or sleeve gastrectomy

Junge, and R

GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation
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For example, interventions that influence myostatin signaling, mTOR activation, or inflammatory cascades may logically support muscle physiology
