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Titrating slowly, spending at least 4 weeks at each dose level, dramatically reduces GI burden

Data reproducibility was maintained through our use of the TriNetX US Collaborative Network, which houses standardized electronic health records from more than 66 healthcare organizations across the United States

The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7

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