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[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Marcellin P., Gane E., Buti M., Afdhal N., Sievert W., Jacobson I.M., Washington M.K., Germanidis G., Flaherty J.F., Aguilar Schall R., et al

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Before switching because of GI intolerance, we recommend ensuring that all reasonable mitigating actions have been implemented, including: 1 ) verifying that the patient is taking the prescribed dose of the current GLP-1 receptor agonist because dose reduction can often minimize or resolve GI symptoms

A total of 13 studies from the past ten years were examined, and while they all showed that losing weight had a good impact on blood pressure, the degree and persistence of this effect differed from study to study

But for most, he says, there's an element of negative reinforcement