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Based on the results, the researchers suggested that patients prescribed GLP-1s continue the medication prior to a procedure but also follow the standard fasting period and go on a liquid diet the day before, until more research is available

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In addition to the higher -helix propensity, the more pronounced amphiphilic nature of exendin-4 enables stronger polar and hydrophobic interactions with the ECD of GLP-1R via opposite sides of the -helix than GLP-1 (vide infra)

These modifiers often apply in infectious, inflammatory, or post-surgical joint management scenarios where repeated aspirations are clinically indicated

The study also plans to conduct a year-long, blinded crossover extension