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However, a systematic review and metaanalysis including three highquality, randomised clinical trials and 18 700 patients diagnosed with diabetes and treated with GLP1RAs or placebo found no significant association [106]

When protein breaks down during digestion, the resulting amino acids interact with receptors in the gut that trigger GLP-1 release

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Jastreboff et al., NEJM, 2023

Research shows these pathways help reduce hunger cues, increase satiety, and regulate caloric intake, making the compound highly relevant to obesity and appetite-control research