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PCOS and GLP-1s: Improving Reproductive Functionality For PCOS, the human evidence on GLP-1 medications is compelling enough that they now feature in the 2023 International PCOS Guidelines, though as a conditional recommendation (1)

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By promoting healthier blood sugar regulation and insulin sensitivity , theyve become a breakthrough therapy for both metabolic and reproductive health

Pharmacological approaches include DPP-4 inhibitors, which prevent GLP-1 degradation, and GLP-1 receptor agonists, both approved by NICE for type 2 diabetes management in appropriate patients according to treatment guidelines