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phase 1 clinical study report in November, while also pushing "Olix 2.0" efforts that include a central nervous system (CNS) delivery strategy and an ALK7 program it is targeting for an investigational new drug (IND) filing in 2027

PMID 15655702

Dipeptidyl peptidase-4 (DPP-4), also known as CD26, is widely expressed in the epidermis and on multiple immune cell subtypes, and preclinical studies demonstrating cutaneous vasculitis in non-human primates with some, but not all, DPP-4 inhibitors [20], has heightened awareness of the potential consequences of DPP-4 inhibition on the skin

Wu F, Yuan Z, Shafiq M, et al

Digestive discomfort is rarely a concern at these levels