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Description
GLP-1 receptors are present in the hypothalamus, and when GLP-1 rises after a meal, it acts directly on the hypothalamus to reduce the alerting signal from orexin neurons
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N Engl J Med 1990
A meta-regression analysis of GLP-1RA CVOT showed that the magnitude of HbA1c lowering, but not body weight (BW) loss, was associated with the prevention of renal outcomes [24]
Phase 1 trial of ALRN-6924, a dual inhibitor of MDMX and MDM2, in patients with solid tumors and lymphomas bearing wild-type TP53
