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The emerging characterization of separate dopamine- and GABA (-aminobutyric acid)-dependent neural systems within the ventral tegmental area (VTA), which can mediate the acute aversive and rewarding psychological effects of nicotine, is providing new insights into how functional interactions between these systems might determine vulnerability to nicotine use

The production of nicotine also plays a large role in the production and energy that goes into the Puff Bar

Atlanta: Centers for Disease Control and Prevention (US), 2014

Tobacco smoking and depressed mood in late childhood and early adolescence