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Gholizadeh-Hashjin A, Monajjemzadeh F, Ghafourian T, Hamishehkar H, Nokhodchi A

Blocking NNMT raises intracellular NAD+ and SAM pools, theorized to drive lipolysis and improve insulin sensitivity in adipose tissue

This is particularly evident in the detection of tissue-specific novel isoforms (e.g., 32 exclusive to gonads), emphasizing the utility of long-read sequencing in elucidating post-transcriptional regulation during gonadal development

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11 To gain further insight into GSH homeostasis, using high-resolution mass-spectrometry metabolic profiling, we documented decreased levels of both sulfur and non-sulfur amino acids involved in GSH-synthesis (serine, betaine, glutamate, cysteine and methionine) as well as metabolites related to GSH-metabolism (-glutamyl-valine and -glutamyl-leucine) in arterial cord blood