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Abdallah Ragda

TEAD inhibitors (estrogen receptor, ER) significantly altered metabolic pathways, such as AMPK and PI3K/AKT signaling and reduced the expression of lipid metabolism related genes such as SREBP1 and 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) (responsible for controlling cholesterol synthesis) by directly binding to their promoters to alleviate hepatic steatosis in HFD-induced MASLD male mice [13]

We therefore examined the protein expression of FOXO3a and p-FOXO3a in the in vitro model

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doi: 10.1089/jmf.2006.9.459 43 MoeinianMFarnaz Ghasemi-NiriSMozaffariSAbdollahiM