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A.K.S., D.H

This approach facilitates personalized interventions such as DGAT1 inhibitors for obese patients exhibiting astrocytic lipid droplet accumulation [278], or NAD + boosters for elderly patients with impaired ketone utilization, as exemplified in the SPAN trial [47, 48, 255]
Unlike cancer cells, CD4 + T cells or Treg cells, CD8 + T cells are unable to adapt to lipid-rich TMEs by shifting their metabolism from glycolysis to oxidative phosphorylation, and the accumulated lipids produce high levels of oxidative stress that ultimately inhibits cytotoxic functions [340]
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Faseb J 17(9):1553

doi: 10.1038/s41467-020-20737-5 101
