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Current evidence indicates that ROS are major mediators of tissue injury in MS, promoting OS that disrupts the structural and functional integrity of lipids, proteins, and nucleic acids ( Under pathological conditions, OS-induced disruption of the BBB facilitates the infiltration of inflammatory cells into the CNS, where they release cytokines and other mediators that amplify neuroinflammation, creating a self-perpetuating pathological cycle
This step, in turn, constitutes a rate-limiting factor for DNA synthesis ( 2.2 Methionine and mTOR pathway The mTOR serves as a central molecular hub that positively governs anabolic processes while simultaneously exerting negative regulation on certain catabolic pathways (Xie and Proud, 2013)

showed that various tocotrienols differ in their potency in inhibiting the proliferation of mouse mammary tumor epithelial cells and in inducing apoptosis [70]
doi: 10.1016/j.chroma.2012.03.068

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