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The dried lipids were derivatized using the Fatty Acid Methylation Kit (Nacalai Tesque, Inc., Tokyo, Japan) and the Fatty Acid Methyl Ester Purification Kit (Nacalai Tesque, Inc.)

Esomeprazole exerts its pharmacological effect by irreversibly inhibiting the hydrogen-potassium ATPase enzyme system (H/K-ATPase) commonly known as the "proton pump" located on the secretory surface of gastric parietal cells

Moreover, SARS-CoV-2 intestinal infection may change gut physiology in general and gut microbiota [30], impacting all aspects that peripherally contribute to the etiology and development of PD [31]

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However, most of these findings are derived from in vitro or ex vivo studies, so studies need to be in vivo to fully capture mitochondrial changes during chronic Mn overexposure at a physiological level