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Furthermore, GSH stores could be depleted from oxidative stress caused by microglial activation and if an individual cannot readily regenerate GSH, low GSH availability may stimulate microglial activation, leading to a cascade of events that potentiates itself
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Indeed, the interconversion of serine and glycine, via the involvement of THF, represents a major pathway for the generation of 5,10-methylene-THF which is a member of the active folate pool

Awadalla A, Hamam ET, El-Senduny FF, Omar NM, Mahdi MR, Barakat N, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 328.Vembadi A., Menachery A., Qasaimeh M.A