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4.3.1 Nrf2 Nuclear factor erythroid 2 (Nrf2), a protein that regulates genes involved in both ferroptosis and inflammatory pathways, represents a target in depression

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There are several known mechanisms that explain its neuro-protective effects: It plays a pivotal role in combating oxidative stress, reducing inflammation, and promoting mitochondrial function, and it is a precursor to glutathione

There is a complex interaction between autophagy and lipid metabolism ( In this review, we first introduce the molecular mechanisms of ferroptosis and then focus on a discussion of regulators of iron metabolism in ferroptosis (Table 1)

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