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While high-potency topical corticosteroids are the mainstay of therapy, combination approaches are often necessary for severe or resistant cases [16]

It is typically prescribed to relieve moderate-to-severe menopausal vasomotor symptoms, treat hypoestrogenism due to ovarian insufficiency, and support feminizing hormone therapy regimens under clinician supervision

Although there is no explicit recommendation regarding their use based on residual -cell function in DKD patients, individualized treatment decisions remain crucial, taking into account aspects such as glycemic control, cardiovascular risk, and tolerability