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In OA, elevated levels of reactive oxygen species (ROS) and lipid peroxidation products such as oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) in chondrocytes induce pain and physical disability [4]
Based on related structural investigations, one key residue of aldehyde dehydrogenases was identified that is of importance for the recognition (or discrimination) of NAD + and/or NADP + (Yuan et al., 2013)
doi:10.1016/0091-3057(82)90264-7
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10.1016/0006-2952(95)00019-V [DOI] [PubMed] [Google Scholar] 9.Chiechio S, Copani A, Nicoletti F, Gereau RWT
