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[PubMed] [Google Scholar] 109.DENING TR, BERRIOS GE & WALSHE JM WILSONS DISEASE AND EPILEPSY

As a consequence, metformin also affects the proteins downstream to these cascades, reducing specifically the eIF4E phosphorylation and the translation of MMP-9 (93), which in the pathological condition is the cause for the degradation of proteins essential for synaptic maturation and activity ( Fmr1 -KO flies and mice models of FXS, showing a rescue of dendritic spine morphology, long-term depression (LTD) of synapses, but also improvement in cognitive, intellectual and social deficits (90, 94)

Acknowledgements We wish to acknowledge the support of all our research group members