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Furthermore, immunofluorescence studies showed that chronic administration of the drugs tested also decreased levels of GFAP, Caspase-3, and BAX in the CA1 and DG of the hippocampus

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,, Although there are several inhibitors of the cystine/glutamate transporter other than sulfasalazine, these drugs have limitations of low bioavailability and low selectivity to of the cystine/glutamate transporter in vivo

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28 (7-8):753-6 Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, and Atsushi Nakajima - Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study - BMC Gastroenterol