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Abbreviations EMT: Epithelial mesenchymal transition TME: Tumor microenvironment TIMER: Tumor Immune Estimation Resource HGSOC: High grade serous ovarian carcinoma EOC: Epithelial ovarian cancer MET: Mesenchymal epithelial transition PBS: Phosphate buffered saline BSA: Bovine serum albumin OCR: Oxygen consumption rate OXPHOS: Oxidative phosphorylation ECAR: Extracellular acidification rate 2-DG: 2 Deoxy glucose TCA: Tricarboxylic acid ECM: Extracellular matrix CTC: Circulating tumor cells G6PD: Glucose-6-phosphate dehydrogenase PPP: Pentose phosphate pathway ITGA2: Integrin alpha-2 ITGAV: Integrin alpha-V ITGA1: Integrin alpha-1 FLNA1: Filamin-A TGFBI: Transforming growth factor induced protein AKR1B1: Aldoreductase GFPT2: Glutaminefructose-6-phosphate aminotransferase HPRT1: Hypoxanthineguanine phosphoribosyltransferase SDPR: Serum deprivation-response protein CALB2: Calretinin ALCAM: CD166 antigen KTN1: Kinectin SEPT2: Septin-6 FSCN1: Fascin FLNC1: Filamin-C PCK2: Phosphoenopyruvate carboxykinase ACACA: Acetyl-CoA carboxylase 1

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Systemic adverse effects appear to be uncommon based on available reports, but comprehensive adverse event profiles are lacking due to the paucity of large-scale clinical investigations